GLOMERULAR FILTRATION BARRIER

 The glomerular capillaries help in filtering blood plasma through the formed barrier called GLOMERULAR FILTRATION BARRIER. This barrier is a critical component responsible for filtering blood and formation of primary urine, which is later processed to produce the final urine. THE GLOMERULAR FILTRATION BARRIER consists of three main layers;

1. Fenestrated Endothelial layer

2. Basement membrane

3. filtration slit


FENESTRATED ENDOTHELIAL LAYER

These are the cells that line the glomerulus capillaries in the glomerulus. They have small gaps or fenestration between them, allowing blood to flow into the glomerulus. Meanwhile, only substances between 70-90nm can pass through this layer.


BASEMENT MEMBRANE 

Beneath the endothelial cells, there is a basement membrane which is a dense layer of extracellular matrix. It acts as a selective barrier preventing the passage of large molecules like proteins from the blood into the urine. Therefore, only substances less than 8nm can pass through this layer.


FILTRATION SLITS

It is formed by the cleft-like space and only substances less than 3nm can pass through this layer.


CONCLUSIVELY, the force responsible for pushing the filtrate down through the glomerular filtration barrier to the bowman capsule is  STERLING'S FORCE, which acts through pressure. 

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